Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium
Summary: DNA damage activates checkpoints that limit the replicative potential of stem cells, including differentiation.These checkpoints protect against cancer development but also promote tissue aging.Because mice lacking Slug/Snai2 exhibit limited stem cell activity, including luminobasal differentiation, and are protected from mammary cancer, w